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DTI and Pediatric Mild Traumatic Brain Injury

New research published online in the December 2012 issue of the Journal of Neuroscience utilized diffusion tensor imaging (DTI) to examine the last affects of a traumatic brain injury in children. The Journal of Neuroscience, 12 December 2012, 32 (50):17961-17969. 

The researchers from Mind Research Network and the University of New Mexico examined fifteen semi-acute pediatric mild traumatic brain injuries as well as fifteen well-matched controls.  A region of interest and voxelwise Analyses indicated increased anisotropic diffusion for pediatric mild TBI patients with an elevated number of clusters with high anisotropy.  Researchers were able to objectively classify pediatric mild TBI patients from healthy controls with a 90% accuracy.  Researchers found little evidence of recovery in white matter abnormalities over a four month interval in returning patients, “indicating that physiological recovery may lack behind subjective reports of normality….  Current findings suggest that developing white matter may be more susceptible to initial mechanical injury forces and that anisotropic diffusion anisotropic diffusion provides a objective bio marker of pediatric mild TBI.” 

An abstract of the article by Mayer, et al. can be found here

An excellent review of the study can be found at the Education Week Spotlight

 

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